I have read too many reports that quality has improved after drying a brand new spool that has just been taken out of a vacuum bag that contains desiccant. It defies logic, but it’s easy to eliminate this one factor. A before and after Benchy with standard presets is the litmus test.
I’ve taken to immediately drying all new spools and then placing them in the AMS or a box with desiccant for my DIY X1C.
It’s standard practice on Stratasys high performance filaments like Ultem, for full and partially-used cassettes, using a vacuum oven, blast oven or even the Fortus build chamber. Partially used filament is resealed in evacuated foil bags with desiccant, but still dried before use.