I only use hybrid tree supports and sometimes depending on the angles will increase the support/object XY distance from the default .35mm up to .38 or .4mm
Z distance is similar with a .2mm default but if there is going to be a lot of support material for larger overhangs I’ll bump my Z gap up to .25
No interface used when I’m using hybrid tree supports but I will use the interface with normal supports for when I’m doing larger prints with big but simple overhangs
The only setting in interface that I’ll muck around with is top interface spacing which seems large at a default of .5mm but I’ve found bumping up my top spacing to .525 makes the removal peel off the model nicer and easier
That’s what works for me, maybe it will work for you
I don’t bother with regular tree supports after one failed print using them because the default settings allowed a couple of the supports to break away and a failed 4 hour print 3 hours into it is a good enough kick in the nuts for me to avoid them until I adjust the settings and dial them in
But why bother dialing in regular tree supports when the hybrid ones work so good ?
Hybrid tree for me 80% of the time
Hopefully (even in a small way) what works for my particular style of printing works for you as well
Good luck 
Edit: I also have a custom .16mm slicer profile that i use so not factory defaults everywhere
Sometimes there’s quite a few small changes that make big differences
If you are interested in my quality, strength, speed, and support settings I’ll happily share
Who knows ? I may not be the sharpest tool in the shed but I can still cut through a lot of the bullsh*t by keeping things simple, sort of, kind of, not really simple but not complicated. It’s complicated to explain but easy to do lol