As a Master Gunsmith and a super Novice 3d printer, I can tell you that a semi-auto pistol lower can be successfully made with PLA Tough + (Bambu) or PLA + (Other brands), ASA, and stronger level filaments without issue, and last for many rounds. PLA and PETG for some reason don’t last “in the field” (In the field meaning range/in use/etc.). The uppers typically need to be metal, to include the barrel, firing pin, extractor, etc., and the lower parts, Fire Control System (trigger, trigger bar, hammer, sear, etc.) should also be metal.
I have made a 1911 from scratch using a self programmed CNC with metal (lower aluminum and upper steal) to include the screws, springs, trigger, trigger bar, hammer, etc. to test things out and have over 2000 rounds through it. (I did not make the barrel (due to not have the right lathe), wood hand grips (due to being crappy working with wood) or sights (wasn’t liking what I was making, and it was cheaper to buy a good set, next time I may perfect that though and make them better than I was.)
I have made a Glock 17 lower from scratch and have over 1500 rounds through it testing it out. No problems what so ever. Granted, I can’t and won’t make them for others, but as a Gunsmith wanted to see what would work and not work… (And I wouldn’t share the files for it either before anyone asks…)
Hybrid guns can and are made successfully and with long term use. Full 100% 3d plastic (in any version of it, PA, PLA, ASA-GF, ASA, etc., I have seen or talked to anyone that has made one that withstands moderate to heavy use yet. It will happen though, I’m sure.