The size can affect layer times and cooling durations when printing with plastics.
I wanted to share this link with you in case you haven’t seen it. It shows how cooling on the H2D affects parts, showing that 100% cooling can sometimes be too much for PLA.
I’ve successfully printed PLA with PETG interface on the H2D without any problems, though I use a variety of different settings rather than the default slicer ones.
I can create a CAD file according to your specifications. I believe I might have some time later on today.