The function of the sock is to prevent the heat from escaping. If you run the hot end without it there is a high chance the heater wont be able to keep the hot end at operating temperature.
I have printed PPA and PPS both at higher temps than standard (for better layer adhesion), close to 350c without any problems or damage to the sock.
TLDR - use the printer like it was designed and keep the sock always on.
Ive had to replace both of mine already. They tend to tear at the rib between the two holes. I wound up ordering 40 pack from aliexpress for $18, I would suggest you inspect them often.
Ive printed both PPA and PPS which I print at close to 350c for better layer adhesion with no problems. Also they have not ripped yet, still on my first ali sock set.