Volumetric speed is kind of a master “speed limit” that lives in the filament profile, and by default this is the same profile regardless of nozzle size. You can change the speeds in the “process” profile as well, and you have more control over the “context” e.g. inner wall, outer wall, infill, etc.
Acceleration setting affect how quickly speed changes apply, when the printer is moving from one speed to another. Once the speed has reached a “steady state” the acceleration setting has no effect.
So if you want to increase the volumetric speed to some huge value, you will never “use” it at all, the other speed settings will kick in first. But I suggest you REALLY don’t want to do this; the max volumetric speed is your “friend” so that you don’t have to change the “process” level speed settings as much.
But using a test model to try to establish an “optimum” for this is misguided. It is easy to see the effect of changes in your print, just change to “speed” and you see colour coded by speed. If you keep lowering the max volumetric speed, you will eventually see that speed limit “kick in” and override the process level settings.
For example in a PETG print I am having problems with inner/outer walls printing “too fast”. I would first establish what speed works in my print by just changing it directly in the process settings. Then do “dial in” that setting for the PETG filament, I can choose to lower max volumetric. However you do it, the bottom line is you are changing the speed for a given trace of filament, which you can see graphically. If something is printing too fast, slow it down. Conversely, if your prints are perfect, dial in your speed settings. I like to check on what is the “bottleneck” in my print, and try to make improvements where they have the most impact.
“First layer” settings have very little impact on the overall print time, so “tweaking” them is unlikely to result in any substantial difference. However if the first layer has defects, you want to eliminate them because they impact overall print quality.
One thing I have noticed is that with a multiple filament print, Studio does not let me adjust the profiles independently, which is too bad.